Conservative Oxygen Therapy During Mechanical Ventilation in the ICU, ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group, N Engl J Med. 2020 Mar 12;382(11):989-998. doi: 10.1056/NEJMoa1903297. Epub 2019 Oct 14.
Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis, Chu, Derek K et al. The Lancet , Volume 391 , Issue 10131 , 1693 - 1705
Interpretation: In acutely ill adults, high-quality evidence shows that liberal oxygen therapy increases mortality without improving other patient-important outcomes. Supplemental oxygen might become unfavourable above an SpO2 range of 94–96%. These results support the conservative administration of oxygen therapy.