Acide Tranéxamique - Tranexamic Acid - Cyklokapron
Tranexamic Acid for Traumatic Injury in the Emergency Setting: A Systematic Review and Bias-Adjusted Meta-Analysis of Randomized Controlled Trials. Fouche PF, Stein C, Nichols M, Meadley B, Bendall JC, Smith K, Anderson D, Doi SA. Ann Emerg Med. 2023 Nov 21:S0196-0644(23)01281-7. doi: 10.1016/j.annemergmed.2023.10.004. Epub ahead of print. PMID: 37999653.
Prehospital Tranexamic Acid for Severe Trauma. PATCH-Trauma Investigators and the ANZICS Clinical Trials Group; Gruen RL, Mitra B, Bernard SA, McArthur CJ, Burns B, Gantner DC, Maegele M, Cameron PA, Dicker B, Forbes AB, Hurford S, Martin CA, Mazur SM, Medcalf RL, Murray LJ, Myles PS, Ng SJ, Pitt V, Rashford S, Reade MC, Swain AH, Trapani T, Young PJ. N Engl J Med. 2023 Jun 14. doi: 10.1056/NEJMoa2215457. Epub ahead of print. PMID: 37314244.
Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. CRASH-3 trial collaborators. Lancet. 2019 Oct 14. pii: S0140-6736(19)32233-0. doi: 10.1016/S0140-6736(19)32233-0. [Epub ahead of print]
INTERPRETATION: Our results show that tranexamic acid is safe in patients with TBI and that treatment within 3 h of injury reduces head injury-related death. Patients should be treated as soon as possible after injury.
CRASH 3: TXA is no wonder drug, First10EM, 28 october 2019: Pas d'amélioration de la mortalité globale.
Effect of Tranexamic Acid in Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Weng S, Wang W, Wei Q, Lan H, Su J, Xu Y. World Neurosurg. 2019 Mar;123:128-135. doi: 10.1016/j.wneu.2018.11.214. Epub 2018 Dec 6. PMID: 30529516
Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010 Jul 3;376(9734):23-32. doi: 10.1016/S0140-6736(10)60835-5. Epub 2010 Jun 14.
1 g IV en 10 min
puis 1 g IV en 8 heures
Enfant = 15 mg/kg
Evaluation of Military Use of Tranexamic Acid and Associated Thromboembolic Events. Johnston LR, Rodriguez CJ, Elster EA, Bradley MJ, JAMA Surg. 2018 Feb 1;153(2):169-175. doi: 10.1001/jamasurg.2017.3821.
Tranexamic acid and trauma-induced coagulopathy, J Intensive Care. 2017; 5: 5. Published online 2017 Jan 20. doi: 10.1186/s40560-016-0201-0