Acide tranexamique

Acide Tranéxamique - Tranexamic Acid - Cyklokapron

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. CRASH-3 trial collaborators. Lancet. 2019 Oct 14. pii: S0140-6736(19)32233-0. doi: 10.1016/S0140-6736(19)32233-0. [Epub ahead of print]

INTERPRETATION: Our results show that tranexamic acid is safe in patients with TBI and that treatment within 3 h of injury reduces head injury-related death. Patients should be treated as soon as possible after injury.

CRASH 3: TXA is no wonder drug, First10EM, 28 october 2019: Pas d'amélioration de la mortalité globale.

Effect of Tranexamic Acid in Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Weng S, Wang W, Wei Q, Lan H, Su J, Xu Y. World Neurosurg. 2019 Mar;123:128-135. doi: 10.1016/j.wneu.2018.11.214. Epub 2018 Dec 6. PMID: 30529516

Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010 Jul 3;376(9734):23-32. doi: 10.1016/S0140-6736(10)60835-5. Epub 2010 Jun 14.

1 g IV en 10 min

puis 1 g IV en 8 heures

Enfant = 15 mg/kg

Evaluation of Military Use of Tranexamic Acid and Associated Thromboembolic Events. Johnston LR, Rodriguez CJ, Elster EA, Bradley MJ, JAMA Surg. 2018 Feb 1;153(2):169-175. doi: 10.1001/jamasurg.2017.3821.

Tranexamic acid and trauma-induced coagulopathy, J Intensive Care. 2017; 5: 5. Published online 2017 Jan 20. doi: 10.1186/s40560-016-0201-0